Australia 466 (M J North 117, M G Johnson 96 no, R T Ponting 83, M J Clarke 68, B J Haddin 63, D W Steyn 4-113) & 207 (P J Hughes 75) v South Africa 220 (A B de Villiers 104 no, M G Johnson 4-25) & 291 (G C Smith 69, H M Amla 57, M G Johnson 4-114)
Australia beat South Africa by 162 runs
Australia bowled out South Africa for 291 to complete a 162-run victory in the first Test at the Wanderers.
The Proteas resumed at 178-2 on the final morning in pursuit of a target of 454, but lost regular wickets as Australia sealed the win shortly after tea.
Mitchell Johnson finished with figures of 4-112 and was ably supported by fellow seamers Peter Siddle (3-46) and Ben Hilfenhaus (2-68).
The tourists, who fielded a new-look line-up including debutants Phillip Hughes, Marcus North and Hilfenhaus, took the first step to bouncing back from the 2-1 defeat to the same opponents on home soil at the turn of the year.
South Africa began the final day requiring a further 276 runs; more realistically their task was to bat out three sessions for a draw.
Australia claimed the wickets of Hashim Amla, AB de Villiers and Jacques Kallis in the morning to end any lingering South African thoughts of victory.
After coming together with the score on 130 late on Sunday evening, third-wicket pair Amla and Kallis initially looked comfortable and brought up their 50 partnership from the first delivery of the day.
Amla completed a personal half-century from 103 balls with a cover drive to the boundary off Johnson shortly afterwards.
But he perished for 57 when an attempt to flick Siddle through the leg-side ended in the hands of Hughes at short square-leg.
And De Villiers followed 19 balls later - via a failed referral - after umpire Billy Bowden gave him out lbw for three.
The batsman was not convinced of Bowden's judgement and asked for the decision to be sent upstairs - but his fate was confirmed by television official Asad Rauf, who eliminated any doubt the ball was sliding down leg side.
The second new ball was taken as soon as it became available and Johnson almost struck straight away when Kallis was trapped low on his pads and given out leg before by Bowden.
He also called for a referral and this time Rauf decided the ball had pitched just outside the line of leg-stump and reversed the initial call.
But Kallis' second chance was shortlived as he played on for 45 in Johnson's next over to leave South Africa struggling at 229-5.
And Australia rammed home their advantage with three more scalps in the afternoon session.
JP Duminy (29) fended a rapid delivery from Siddle to second slip to end a 39-run stand with Mark Boucher for the sixth wicket.
Morne Morkel (2) lasted just 12 balls before top edging an attempted pull to be caught by Hughes at mid-on and give Johnson his third wicket.
And Mark Boucher's 105-ball vigil for 24 was ended when Hilfenhaus nipped an off-cutter between his bat and pad, leaving the Proteas hurtling towards defeat on 289-8 at tea.
Australia needed just eight balls of the final session to complete the win. Siddle had Paul Harris (8) caught at short-leg by Simon Katich and Johnson finished things off by clean bowling Steyn (6).
The Queensland left-arm seamer finished with the eight wickets in the game and also scored 96 not out in Australia's first innings of 466 to earn the man-of-the-match award.
The three-match series continues with the second Test in Durban from March 6-10.