Spinner Majid Haq became Scotland's leading ODI wicket-taker with three scalps against Pakistan, but it was not enough to stop the hosts going down by 96 runs in Edinburgh.
Pakistan won the toss and choose to bat at the Grange, and after making 231-7 the cantered to victory by bowling Scotland out for just 135.
Clydesdale bowler Haq did have some cause for celebration as he moved clear of John Blain when taking his ODI tally to 44 wickets - although he then went on to get out for a duck during Scotland's run chase.
Pakistan were using the fixture as a warm-up for their Champions Trophy campaign, which begins against the West Indies at the Oval in London on June 7, but were sluggish with their scoring.
The slow pitch at the home of Scottish cricket seemed to catch out the tourists early on, with Nasir Jamshed (20) first to fall while Mohammad Hafeez (18) followed as Haq grabbed his first wicket of the day when Josh Davey caught the batsman at backward point.
Imran Farhat missed out on his half century as he was then bowled by Haq's fellow spinner Matt Machan while attempting an ugly slog on 49.
Haq did the same to Asad Shafiq (seven) before claiming Umar Amin (three) as he tried and failed to smash the ball over Rob Taylor at deep mid-wicket, while Akmal mustered just 12 before being trapped lbw by Neil Carter.
Pakistan's attempt to manufacture a quicker run rate up until this point had only led them into trouble but the 51-run seventh-wicket partnership by skipper Misbah-ul-Haq and Ajmal steadied their nerves before the latter fell for 28 as he tried an orthodox scoop off Wardlaw's delivery, only to see it carry straight on and hit his stumps.
Misbah carried on past his half century to finish 78 not out and set up a tally the proved much too high for the Scots - as Junaid Khan and Saeed Ajmal both took three wickets apiece.
The match had been Northamptonshire batsman Kyle Coetzer's first as Scotland skipper after he was named Gordon Drummond's replacement earlier this week, and he led by example as he top scored for the home side with 32.
But in the end it proved to be a simple job for Pakistan to rattle through Scotland's lower order, with Rob Taylor (13) falling at the death as Ajmal claimed another lbw to leave him tied alongside Khan.
The teams will meet again in the second leg of their ODI double-header on Sunday.