Lancashire suffered a disastrous start to their Division One title defence as Sussex wrapped up a 10-wicket victory inside three days at Aigburth.
Last year's champions slipped from 39-3 at the start of play in their second innings to 176 all out - leaving Sussex just one run for victory.
Ashwell Prince made 65 and Luke Procter added 46, but there was little resilience elsewhere in the home side's ranks in Liverpool.
Sussex's Australian debutant Steve Magoffin removed Prince and Glen Chapple to take his innings haul to five, after removing the top three last night, and ended with stunning figures of 7-34 with the wickets of Kyle Hogg and Simon Kerrigan.
England spinner Monty Panesar also claimed three wickets for Sussex, who return home from Merseyside with 22 points for their efforts.
Lancashire accrued just three points from their season-opener.
Michael Yardy scored the 18th first-class century of his career to help put Sussex on course for victory against Lancashire at Liverpool.
The Sussex skipper added an important 40 runs to his overnight 70 as the visitors made 300 in reply to Lancashire's first-day 124 all out, ensuring a commanding first-innings lead of 176.
Yardy stifled home hopes of early wickets with some dogged batting to advance their overnight score from 137-3.
Pitch conditions may have been more batsman-friendly during the second day but Yardy and Ed Joyce (64) punished some loose bowling with a fourth-wicket stand of 164. Yardy finished with 110 off 171 balls, including nine fours.
Lancashire were hamstrung by four dropped catches, two of them going to Paul Horton at first slip and two of them letting Yardy off the hook on 85 and 98.
And he then watched Australian debutant Steve Magoffin rip through Lancashire's top order after tea with three wickets to reduce the hosts to 39-3 in their second innings.
Ashwell Prince and Luke Procter, who had earlier impressed with the ball, then ensured there were no further alarms as the reigning champions closed on 85-4, still 91 behind.
Sussex seized control of their LV= County Championship Division One match with Lancashire at Liverpool after notable contributions from James Anyon, Michael Yardy and opening batsman Ed Joyce.
Anyon claimed his second five-wicket haul in a week as Sussex bowled their hosts out for 124 and, after an early wobble, the visitors finished the day in a position of strength ar 137-3.
Australian overseas seamer Steve Magoffin got the ball rolling for Sussex as he quickly removed Stephen Moore, who shouldered arms to a straight one, and Gareth Cross.
Anyon then took centre stage as he took 5-36 from 14.2 overs to follow on from his five-for against Surrey in last week's defeat.
He had Paul Horton caught in the slips and South Africa's Ashwell Prince caught behind in his opening spell before returning to trap Karl Brown lbw before lunch.
The 28 year-old then got Chapple caught and bowled and finished the innings
when Hogg chipped him to deep midwicket.
Lancashire responded well with the ball and looked to have got right back into the contest as Chris Nash, Luke Wells and Murray Goodwin all departed to leave Sussex wobbling on 15-3.
But Yardy, in an unbroken fourth-wicket partnership of 122 with the watchful Joyce (48 not out), steadied the ship with an aggressive unbeaten 70 to ensure the visitors finished the day with a 13-run lead.