Captain David Hussey struck 52 off 28 balls to see Nottinghamshire home by four wickets against Lancashire in their Friends Life t20 match.
The Outlaws had lost the six previous meetings between the two sides at this venue but they chased down 156 with 14 balls to spare.
Hussey, 35, is one of only three men to have scored over 5,000 Twenty20 runs and he shared a crucial fourth-wicket stand of 78 in just 7.3 overs with opener Alex Hales, who made 49 off 37, to take the visitors within sight of victory.
It rendered Mitchell McClenaghan's 5-29 - Lancashire first five-wicket haul in t20 - meaningless after he had struck with his first ball on his debut.
Lancashire recovered from the early losses of Stephen Moore and Ashwell Prince as they slipped to 22-2 in the fourth over after losing the toss.
Moore was run out following a mix-up after just six balls and Prince caught in the deep off Ajmal Shahzad in the fourth over.
Steven Croft and Simon Katich, who added 52 and 48 respectively, then shared 93 in 11.2 overs for the third wicket to get their side back on track and up to 115 for two after 15 overs.
But they lost four wickets in the last five overs to halt any momentum gained.
Nottinghamshire fielded superbly with five catches in the deep, the best of which came from diving New Zealander Ian Butler at long-off to get rid of Tom Smith at the end of the 18th over off the excellent Harry Gurney, who finished with 1-18.
Lancashire had their noses in front with the visitors at 50-3 in the seventh over of their chase but Hussey, in particular, and Hales took the game away from them.
Having got Michael Lumb and Riki Wessels early, McClenaghan snared Hussey, Hales and Chris Read but was not enough as the visitors made it two wins out of two.