Australia beat England by 51 runs in the fifth ODI in Brisbane to take an unassailable 4-1 lead in the series.
Captain Michael Clarke ignored the boos that greeted his arrival at the crease to anchor Australia's innings with 54, as the hosts made 249 all out in their 50 overs.
Chris Woakes - playing in just his second one-day international - took 6-45 from his 10 overs, the best figures by an English bowler on foreign soil in the format.
England's reply was quickly in trouble at 22-3 and once Kevin Pietersen holed out to Brett Lee on the boundary, the writing was on the wall.
The tourists were all out for 198 despite a late show of defiance from Jimmy Anderson and Steve Finn, who put on an England 10th-wicket record stand of 53.
Adding to England's worries was a leg injury to Ajmal Shahzad, while Chris Tremlett was ruled out before the game with a slight side strain, which threatens to further deplete a bowling attack that is already without Graeme Swann and Tim Bresnan after they flew home due to injury last week.
Clarke's decision to bat first looked sound while Australia openers Shane Watson and Brad Haddin added 48 inside the first 10 overs.
But Warwickshire youngster Woakes struck in the first over of a spell on three occasions to derail the home side's hopes of a big score.
Hs first wicket came from just his second ball when Watson (16) cut viciously to point where Paul Collingwood held a sharp chance.
Finn, who was handed his one-day international debut in place of Tremlett, claimed his first scalp by yorking Haddin (37) before Clarke received a hostile reception on his way to the middle.
The 29-year-old has has become the focus of criticism in Australia following a barren winter with the bat, but seemed to at least win over some of his doubters as he reached 50 for just the second time during England's tour.
Clarke started fluently, taking 17 from his first 13 deliveries, although his scoring rate turned to a trickle, using 39 balls for his next 18 runs as the loss of Shaun Marsh (16) and Cameron White (16) provoked caution.
David Hussey bedded in alongside his skipper during a rebuilding 65-run stand off 95 balls, before Woakes returned again to make an immediate impact.
This time he needed just one ball to strike, Hussey (34) chopping onto his own stumps.
Clarke, however, advanced to his half-century to win over the locals, although the New South Welshman failed to cash in on their renewed support, soon after top-edging a pull off Woakes that Andrew Strauss easily held running in from cover.
Woakes completed a five-wicket haul when John Hastings (13) lifted him to Collingwood in the deep before Lee (0) sliced to deep third-man to give the 21-year the second best figures by an England bowler in ODIs - only bettered by Collingwood's 6-31 against Bangladesh at Trent Bridge in 2005
England's chase began poorly in the face of a feisty opening spell from Lee (2-21), who had targeted Strauss with a couple of well-aimed bouncers before he accounted for Matt Prior (14) for the third time in the series.
Prior paid for an unconventional stroke to have his off stump pinned back before Strauss (3) followed him from the first ball of Doug Bollinger's next over, pulling tamely to Steve Smith.
Lee was on a hat-trick when Jonathan Trott, England's centurion in Adelaide on Wednesday, was unlucky to flick his first ball straight to Bollinger at short fine-leg.
New man Ian Bell ducked under a bouncer from the hat-trick ball before combining with Pietersen in a rebuilding mission.
They put on 73 without fuss, with Pietersen particularly impressive before he meekly surrendered his wicket.
Pietersen miscued a slower short ball from Hastings to prompt a second mini-collapse of three for eight and virtually seal England's fate.
Eoin Morgan (2) needlessly holed out in the deep off Smith soon after and when Bell (36) chopped on off Hastings, England were 103-6.
The last recognised batsman Collingwood (18) was then caught in the deep from Watson's first ball before the margin of defeat was only reduced by a 53-run stand between last pair Anderson and Finn, the latter clubbing 35 from 24 balls.