Quevega is the star name among 36 entries for the OLBG Mares' Hurdle on the opening day of the Cheltenham Festival.
The Willie Mullins-trained nine-year-old has won the two-and-a-half-mile Grade Two prize for the last four years and is bidding to become only the second horse to win a race at the Festival on five occasions following Golden Miller, who captured the Cheltenham Gold Cup five times between 1932 and 1936.
Should Quevega fail to fire on what is her first start of the season, the Irish champion trainer could still win the race with talented stable companions Reine Angevine, Tarla, Twigline and Zuzka all in contention.
Nicky Henderson has entered top-class French import Utopie Des Bordes and last season's Fred Winter winner Une Artiste, who is unbeaten this term, while Emma Lavelle could be represented by Cleeve Hurdle third Kentford Grey Lady.
Other contenders include Paul Webber's Alasi and the Oliver Sherwood-trained Mischievous Milly.