Frankel has become the first horse to be named Cartier Horse Of The Year for a second successive season.
Sir Henry Cecil's superstar took his unbeaten record to 14 races before being retired in the wake of victory in the QIPCO Champion Stakes at Ascot last month.
The colt has been a Cartier champion in each of his three seasons, winning the Juvenile Colt award in 2010 and being named Horse Of The Year in 2011 after a season in which he won the QIPCO 2,000 Guineas.
Cecil said: "All of us at Warren Place are thrilled that Frankel's achievements this year have been recognised with him winning this most prestigious award for the second time running.
"Frankel with his brilliance has been a great ambassador for British Racing and has captured the hearts of so many people, some of whom have never been racing in their lives. Thank you Frankel and to everyone that has voted for him."
Harry Herbert, Cartier's racing consultant, added: "Frankel lit up all our lives with his magnificent performances in 2012 and during the previous two years.
"He is the most successful horse in the 22-year history of the Cartier Racing Awards and that is no surprise given his domination of so many races. Sir Henry Cecil thinks there has never been a better racehorse and tonight we celebrate Frankel's achievements and those of the team behind him."
There was a victory for Australia in the Cartier Sprinter Award with the world's leading race mare Black Caviar narrowly seeing off the challenge of July Cup winner Mayson.
Camelot held sway in the Cartier Three-Year-Old Colt Award after winning the 2,000 Guineas, Epsom Derby and Irish Derby, his defeat in the St Leger never looking like denying him victory in that category.
The other awards went to The Fugue (Cartier Three-Year-Old Filly), Dawn Approach (Cartier Two-Year-Old Colt), Certify (Cartier Two-Year-Old Filly) and Colour Vision (Cartier Stayer).