Voler La Vedette won't run in the Boyne Hurdle at Navan on Sunday and is heading straight to Cheltenham for a clash with Big Buck's.
Connections had been considering running her at the weekend, in a race she won last year, but will now head to Prestbury Park with a fresh horse.
"I've had a chat with the owners and we've decided she won't run at the weekend. She'll go straight to Cheltenham for the World Hurdle," said trainer Colm Murphy.
"We'll just keep her ticking over now. She seems in great form and I'm very happy with her.
"It's more than likely she'll go for the World Hurdle, not the (David Nicholson) Mares' Hurdle."
Voler La Vedette has enjoyed a successful campaign so far, winning her first three races of the winter, including the Grade One Hatton's Grace Hurdle before suffering defeat against Zaidpour in the Galmoy Hurdle at Gowran Park last month.