Midnight Chase is among the entries for the Betfair-sponsored Rowland Meyrick Handicap Chase at Wetherby on Boxing Day.
The nine-year-old won three fiercely competitive Cheltenham handicaps last season to rise through the chasing ranks.
He signed off for the season with a highly creditable fifth in the Cheltenham Gold Cup.
Midnight Chase was well beaten when falling on his seasonal return at Down Royal, but trainer Neil Mulholland is hopeful his star turn can bounce back in West Yorkshire.
"Everything is grand. The Rowland Meyrick has been his target for a while and, all being well, all roads lead to Wetherby," said Mulholland.
"Fingers crossed everything goes right with him for the next week and the weather is kind to us.
"Decent ground would suit him well."
Midnight Chase looks likely to face a stiff task in the competitive handicap as he sits 11lb clear of the remaining contenders on official ratings.
Nicky Henderson has handed recent Aintree winner Master Of The Hall an entry in the Grade Three contest, while Wayward Prince and Sarando could bid to get their seasons back on track after disappointing in the Hennessy Gold Cup at Newbury.
Impressive Kelso winner Always Right is also a major contender for owner-trainer John Wade.
Other interesting candidates include Haydock scorer Cappa Bleu, Tom George's French recruit Halley and course winner Lackamon.