Harris English and Matt Kuchar took a stranglehold on the Franklin Templeton Shootout in Naples, Florida, with a 12-under-par second round.
The American pair responded well to a charge by Retief Goosen and Freddie Jacobson by producing the best score of the day under the better-ball format.
The latter pair managed 11 under for the day, as did all-English team Lee Westwood and Ian Poulter to jump to third place.
English and Kuchar were one of three pairs tied for the lead after Friday's modified alternate shot round and kept their form going in round two, though South African veteran Goosen and his Swedish partner moved within a shot at one point.
The leaders responded well, though, and pulled four shots clear at 20 under with a strong finish.
Goosen and Jacobsen were a further three clear of Poulter and Westwood, whose 13-under total saw them catch another of Friday's leading pairs, Charles Howell III and Justin Leonard.
Chris DiMarco and Billy Horschel were eight under for the day and 12 under in total, one ahead of Sean O'Hair and Kenny Perry - the final Friday pace-setters - and Rory Sabbatini and Scott Verplank.
Jonas Blixt and Greg Norman moved off the foot of the standings with a brilliant nine-under-par score, having been only level par on Friday, while Jerry Kelly and Steve Stricker were eight under.
The Canadian duo of Graeme DeLaet and Mike Weir were seven under, level with Jason Dufner and Dustin Johnson, while Mark Calcavecchia and Chad Campbell propped up the standings on six under.