Sergio Garcia will play Alvaro Quiros after the seeds were placed into their groups for this week's Volvo World Match Play Championship.
McDowell will play Karlsson at Match Play event in Marbella
Sergio Garcia against fellow Spaniard Alvaro Quiros and Justin Rose against English countryman Robert Rock will be two of the group clashes in this week's Volvo World Match Play Championship in Spain.
In a change from last year, only the best-ranked 16 players in the 24-strong field have been seeded for the group stage, while the remaining eight players will go into a draw on Tuesday to join them.
Defending champion Ian Poulter will have Australian John Senden in his group at Finca Cortesin near Marbella.
The top-ranked player taking part is world number nine Martin Kaymer and he will meet Rafael Cabrera-Bello, the other Spanish player in the line-up.
The format sees eight groups of three, with the leading two players in each after the round-robin games going through to the knockout phase.
Groups so far (seedings in brackets):
(1) Martin Kaymer and (16) Rafael Cabrera Bello
(2) Justin Rose and (15) Robert Rock
(3) Charl Schwartzel and (14) Nicolas Colsaerts
(4) Graeme McDowell and (13) Robert Karlsson
(5) Sergio Garcia and (12) Alvaro Quiros
(6) Peter Hanson and (11) Paul Lawrie
(7) Brandt Snedeker and (10) Thomas Bjorn
(8) Ian Poulter and (9) John Senden
The remaining eight players who will be drawn into the groups on Tuesday are (world rankings in brackets):
(65) Branden Grace
(66) Retief Goosen
(70) Darren Clarke
(119) Jbe Kruger
(126) Camilo Villegas
(133) Tetsuji Hiratsuka
(175) Tom Lewis
(218) Richard Finch
