Ernie Els has been forced to pull out of next week's PGA Grand Slam of Golf in Bermuda after suffering an ankle injury.
The Open champion will be replaced in the four-man field by Padraig Harrington in the 36-hole event at the Port Royal Golf Club in Bermuda.
The South African's withdrawal is another blow for organisers after PGA champion Rory McIlroy opted to miss the tournament to play at the BMW Masters in Shanghai.
McIlroy was replaced by 2011 PGA Championship winner Keegan Bradley, who will line up alongside Harrington, Masters champion Bubba Watson and US Open victor Webb Simpson.
Harrington said: "While my entry is under unique circumstances, I am excited to compete in the event again. I came close the last two times I was there, losing in play-offs to Angel Cabrera in 2007 and Jim Furyk in 2008, so maybe the third time will be a charm."
Els revealed that his sprained ankle is not a serious issue, although he was advised not to play in Bermuda on medical advice.
"I am bitterly disappointed," said Els, winner in 1997 and 2010.
"It is a great reward for winning a major and something I have enjoyed in the past and was looking forward to again.
"Unfortunately I sprained my left ankle a few days ago and while it isn't too serious and should recover relatively quickly, I have been advised not to try and play on it."