Napoli lost 2-0 to Young Boys in Bern in the Europa League on Thursday, as Feyenoord went down 3-1 away to HNK Rijeka.
Mario Gotze and Philipp Lahm hit braces as Bundesliga leaders Bayern Munich romped to a 6-0 victory over Werder Bremen.
Freiburg are still waiting for their first Bundesliga win of the season after they fell to a 2-1 defeat at home to high-flying Wolfsburg.
Bas Dost has been linked with a move away from Wolfsburg, but the Bundesliga side insist he remains part of their plans.
Borussia Monchengladbach and Mainz both preserved their unbeaten league records this season as they recorded a 1-1 draw.
Fiorentina cruised to a 3-0 win at Dinamo Minsk in the Europa League, while Villarreal thrashed Apollon Limassol 4-0.
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