Manchester United take on leaders Chelsea on Super Sunday, while Liverpool welcome Hull City to Anfield on Saturday.
Merse predicts wins for Chelsea, Spurs, QPR and Man City - but sees Arsenal slipping up at Sunderland.
Real Madrid face Barcelona on Saturday in the first El Clasico of the season, with Luis Suarez set to make his debut.
QPR must keep starting Bobby Zamora, says Jamie Carragher, and hold fire on recalling Adel Taarabt.
Louis van Gaal has played down his role in Jose Mourinho's development, saying he became the Special One all by himself.
Hugo Rodallega scored twice as Fulham beat London rivals Charlton 3-0 at Craven Cottage in the Championship on Friday.