Alvaro Morata scored as Spain beat Ukraine 1-0 in Friday's European Qualifiers, while Slovakia won to stay top of Group C.
Darren O'Dea concedes the political situation in eastern Ukraine made it virtually impossible to play there.
Germany beat European champions Spain 1-0 in Tuesday night's friendly thanks to a late goal from Toni Kroos.
San Marino claimed the first European Championship qualifying point in their history after a stalemate with Estonia.
Find out more about Sky Sports' live coverage of 250 European Qualifiers this season.
Spain will not defend their European Under-21 Championship title after they were beaten in the qualification play-offs.
Ukraine earned their second win in four days with a 1-0 victory over Macedonia in their European Championship qualifier.
Ukraine got their points tally moving in the European Qualifiers by edging a tight battle with Belarus 2-0 in Borisov.
Paco Alcacer will be hoping to play an important part when Spain travel to European Qualifying Group C leaders Slovakia.
Spain took the first steps on the road to recovery from their World Cup woe with a 5-1 win over Macedonia in Valencia.
UEFA have approved the launch of a Nations League from 2018, with the new tournament to be played every second year.
Ukraine must play their first home qualifier for the 2018 World Cup behind closed doors after a failed appeal to FIFA.
France produced a stunning comeback in their World Cup play-off beat Ukraine 3-0 in Paris and progress 3-2 on aggregate.
Blaise Matuidi wants France to play "with heart, with guts and with the head" as they bid for a place at the World Cup.
Two-goal star Mamadou Sakho insisted he was no hero after firing France to the World Cup finals on Tuesday night.
Ukraine are in control of their World Cup qualification hopes after beating France 2-0 in their first leg play-off tie.
France have been given a tough draw against Ukraine in the World Cup play-offs, while Portugal will meet Sweden.
The eight European teams in the World Cup play-offs will find out who they will face when the draw is made on Monday.
England will not be seeded for the World Cup draw in December despite moving up to No 10 in the world rankings.
Ukraine demolished San Marino 8-0 on Tuesday night but it was still not enough to lift them to the top of Group E.