Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals - but England's top flight lags behind rest of Europe.
Sassuolo defeated 10-man Udinese 1-0 on Sunday afternoon to continue their strong finish to the season.
Roma rallied from behind to beat Udinese 2-1 and return to second place in the Serie A table.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Roberto Soriano struck twice as Sampdoria halted a six-match winless run with a 4-1 triumph at Udinese.