Napoli slumped to their second straight Serie A loss as Udinese snatched three points at the Stadio Friuli.
Juventus joined Roma at the top of Serie A with two wins out of two this season after beating Udinese 2-0 on Saturday.
AC Milan beat Lazio 3-1 in Filippo Inzaghi's first Serie A game in charge, while Inter Milan's Nemanja Vidic saw red.
Antonio Di Natale struck twice as Udinese won 2-0 at home to promoted Empoli in Serie A.
Udinese have signed Greece international midfielder Panagiotis Kone from relegated Bologna.
Sunderland ended their pre-season campaign with a 2-0 win over Serie A outfit Udinese.
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