Real Sociedad suffered their second defeat in eight league games under David Moyes when they lost to Rayo Vallecano.
Spain striker Alvaro Negredo came off the bench to head in the decisive goal as Valencia beat his old club Almeria 3-2.
Barcelona beat Atletico Madrid 3-1 on Sunday night to move to within a point of Real Madrid at the top of La Liga.
Sevilla climbed up to fourth place in the Primera Division standings thanks to a 2-0 away win at Almeria on Sunday.
Almeria beat Malaga 2-1 at La Roseleda Stadium to make it three wins in a row for Juan Ignacio Martinez.
Watch the best strikes from the past 12 months in Spanish football and vote for your Goal of the Year.
Stand-in goalkeeper Julian Cuesta was the hero as Almeria tasted victory in the league for the first time since September.
The Madrid derby is one of five mouth-watering Copa del Rey cup ties on Sky Sports this week.
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