Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Stephan El Shaarawy scored twice as AC Milan recaptured some of their fading flair with a 3-0 victory over Torino.
Torino retain an outside chance of sneaking into the Europa League after dominating Chievo to win 2-0 on Sunday.
Genoa reached seventh place in the Serie A table by keeping European rivals Torino firmly under control in a 5-1 win.
Empoli's long wait for a second away win of the Serie A season came to an end with a 1-0 victory at Torino on Wednesday.