Substitute Clinton N'Jie's late strike earned Lyon a 1-0 victory at Rennes in their final game of the season.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Reims secured their place in Ligue 1 for next season with a 1-0 victory over Rennes.
PSG are on the brink of winning the Ligue 1 title after Caen stunned Lyon 3-0 on Saturday, while Metz were relegated.
Ten-man Bastia maintained their late-season revival and ended Rennes' six-match unbeaten run with a 1-0 victory.
Rennes extended their unbeaten record at home to six games as a last-minute goal earned a 2-1 victory over Nice.