Monaco sealed a spot in the Champions League thanks to a 1-0 win at Lorient in the final round of Ligue 1 matches.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
St Etienne beat Guingamp 2-1 but it was not enough to propel them into the Champions League.
Evian's relegation to Ligue 2 was confirmed on as a late penalty condemned them to a 2-1 defeat to St Etienne.
Marseille kept their hopes of Champions League qualification alive after a late comeback saw them beat Monaco 2-1.
St Etienne strengthened their grip on European qualification by hammering Nice 5-0 at the Stade Geoffroy-Guichard.