Alvaro Morata scored as Spain beat Ukraine 1-0 in Friday's European Qualifiers, while Slovakia won to stay top of Group C.
San Marino claimed the first European Championship qualifying point in their history after a stalemate with Estonia.
Slovakia registered their second win in four days with a 3-1 European Championship qualifying victory over Belarus.
Paco Alcacer will be hoping to play an important part when Spain travel to European Qualifying Group C leaders Slovakia.
Find out more about Sky Sports' live coverage of 250 European Qualifiers this season.
Spain took the first steps on the road to recovery from their World Cup woe with a 5-1 win over Macedonia in Valencia.
Substitute Alexander Kerzhakov scored a late winner as Russia overcame Slovakia 1-0 in St Petersburg.
UEFA have approved the launch of a Nations League from 2018, with the new tournament to be played every second year.
Gibraltar marked their European debut with a creditable 0-0 draw against Slovakia.
Gibraltar will make its senior international debut in November with a friendly against Slovakia.
Milivoje Novakovic hit a hat-trick as Slovenia ended the World Cup hopes of Norway with a 3-0 victory in Maribor.
Bosnia completed a comeback to win 2-1 against Slovakia to keep their hopes of reaching a first major tournament alive.
Bosnia's World Cup hopes suffered a setback as the Group G leaders slipped up 1-0 at home to Slovakia in Friday's qualifier in Zenica.
Liverpool's Martin Skrtel has confirmed that he has strained knee ligaments but hopes to be back in training this week.
Liechtenstein claimed just their second point of the World Cup qualification campaign with a draw against Slovakia.
Slovakia conceded an injury-time equaliser to draw 2-2 with Latvia in World Cup qualification Group G.
Slovakia were denied a share of second place in Group G as Lithuania ground out a creditable 1-1 draw.
Bosnia host Greece in World Cup qualifying Group G on Friday, as Liechtenstein meet Latvia and Slovakia face Lithuania.
Portugal suffered a surprise home defeat by Ecuador as Russia, Belgium and the Czech Republic all picked up wins.
Jan Kozak has been named as the new coach of the Slovakia national team.