Napoli moved to within three points of second-placed Roma in Serie A thanks to a 2-0 win over Sassuolo.
Inter Milan battled to a third straight Serie A win, 2-1 at Cagliari, while third-placed Napoli beat Sassuolo 2-0 on Monday.
Mohamed Salah celebrated his first Fiorentina start with a goal as the Viola beat Sassuolo 3-1.
Roma beat Cagliari 2-1 to snap a four-game winless streak and close the gap on Serie A leaders Juventus to seven points.
Sampdoria lost further ground in the race for a spot in next season's Champions League after being held at home to a 1-1 draw by Sassuolo on Sunday.
Sampdoria players go into Sunday's game against Sassuolo with criticism from Sinisa Mihajlovic ringing in their ears.
Napoli took advantage of slip-ups by the top five in Serie A with a win at Chievo, thanks to a Manolo Gabbiadini brace.
Sassuolo climbed above Inter Milan in the Serie A standings with a 3-1 win over Roberto Mancini's men on Sunday.
Marco Parolo scored twice as Lazio heaped more woe on Milan, who had Philippe Mexes sent off in a 3-1 defeat.
Luca Rossettini scored at both ends of the field, but ended up on the winning side as Cagliari beat Sassuolo 2-1.
Juventus moved five points clear in Serie A with a 4-0 win over Hellas Verona on Sunday, while Sampdoria beat Parma.
A last-gasp penalty from Ioannis Fetfatzidis denied Sassuolo victory as Genoa came from behind three times to earn a point.
Nigel de Jong scored a late winner as AC Milan edged past Sassuolo 2-1 in their Coppa Italia last-16 clash.
Kamil Glik headed home a deserved late equaliser for Torino as 10-man AC Milan's fortune finally ran out at the Stadio Olimpico.
Sassuolo and Udinese took a point each from a 1-1 draw which the hosts will feel should have ended in their favour.
Roma edged Udinese 1-0 on Tuesday afternoon to close the gap on Serie A leaders Juventus to a point.
Sassuolo claimed a famous 2-1 victory over AC Milan at San Siro on Tuesday afternoon.
Cesena emerged from the fog of Reggio Emilia with a last-gasp equaliser to snatch a 1-1 draw with Sassuolo.
Palermo brought an end to Sassuolo's rise up the Serie A standings and furthered their own with a dramatic 2-1 win.
Roma needed two late goals from Adem Ljajic to deny plucky Sassuolo an historic victory in a Serie A match at the Stadio Olimpico.
No Sky Sports contract? No problem, you can watch a huge weekend of sport on NOW TV.