Improving Sassuolo battled back from a half-time deficit against Empoli to record their second 3-1 victory in four days.
Parma's season went from bad to worse on Saturday as they were beaten 3-1 at home by local rivals Sassuolo.
Roma missed the chance to move to the top of Serie A as they were held to a 0-0 draw at Sampdoria on Saturday, while Parma lost at home to Sassuolo.
Juventus dropped their first Serie A points of the season when they were held to a 1-1 draw at Sassuolo.
Leonardo Bonucci struck the winner four minutes from time as Juventus ended Roma's perfect Serie A run with a 3-2 win.
Ten-man Lazio edged Sassuolo 3-2 on Sunday to secure back-to-back Serie A wins for the first time this season.
Live only on