Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Sassuolo defeated 10-man Udinese 1-0 on Sunday afternoon to continue their strong finish to the season.
Domenico Berardi's hat-trick fired Sassuolo to a 3-2 victory over nine-man AC Milan on Sunday afternoon.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Cesena's relegation from Serie A was confirmed as they let a two-goal lead slip to lose 3-2 at home to Sassuolo.