Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Substitute Samuel Eto'o struck a last-gasp equaliser at Empoli but Sampdoria's European hopes were ended.
Lazio are potentially just one win away from booking their place in the Champions League after beating Sampdoria 1-0.
Inter Milan are in danger of missing out on a European place after goalkeeper Samir Handanovic gifted champions Juventus a 2-1 victory.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Roberto Soriano struck twice as Sampdoria halted a six-match winless run with a 4-1 triumph at Udinese.