Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Fiorentina qualified for the Europa League by holding Palermo at bay to win 3-2 at the Stadio Renzo Barbera.
Cagliari lost 1-0 at home to Palermo to suffer relegation and have their 11-year run in Serie A come to a painful end.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Ten-man Atalanta boosted their Serie A survival hopes with a 3-2 triumph at Palermo on Sunday afternoon.