Zlatan Ibrahimovic scored a hat-trick in Paris Saint-Germain's 5-0 win over Saint-Etienne, while Lyon were beaten again.
Metz scored twice in the last 10 minutes to beat Lyon 2-1 on Sunday.
Lens picked up their first win of the new season with a 1-0 success at Lyon.
Monaco and Lens won 1-0 away to Nantes and Lyon respectively in Ligue 1 on Sunday, as Saint-Etienne and Rennes drew 0-0.
Lyon playmaker Clement Grenier is set to undergo surgery after picking up an injury in the Europa League.
Villarreal, Real Sociedad, PSV Eindhoven and Dinamo Zagreb all enjoyed wins in the Europa League qualifying play-offs.