Napoli will be without defender Juan Zuniga and midfielder Jorginho for Thursday's clash at Slovan Bratislava.
Attention will be focused on Inter boss Walter Mazzarri and Napoli coach Rafael Benitez, in the Europa League this week.
Cagliari moved off the foot of the Serie A table as Albin Ekdal's 15-minute hat-trick saw them beat 10-man Inter Milan.
Napoli survived a late Sassuolo surge to ease the pressure on under-fire boss Rafael Benitez with a 1-0 win.
Former Manchester City boss Roberto Mancini has denied claims that he will take over from Rafael Benitez at Napoli.
Napoli striker Gonzalo Higuain has rubbished suggestions that he is seeking a move away from the Serie A club.