Monaco sealed a spot in the Champions League thanks to a 1-0 win at Lorient in the final round of Ligue 1 matches.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Lens ended a difficult campaign on a high after an early Pablo Chavarria goal earned them a 1-0 home victory over Nantes.
Lorient secured their Ligue 1 status with a 1-1 draw at Nantes on Saturday.
PSG are on the brink of winning the Ligue 1 title after Caen stunned Lyon 3-0 on Saturday, while Metz were relegated.
Diego Rolan scored a goal in each half as Bordeaux beat Nantes 2-1 in their final game at Stade Chaban-Delmas.