Hertha Berlin fell to their third straight defeat as Hannover rose to fifth with a 2-0 win in the capital.
Borussia Monchengladbach ended Hoffenheim's unbeaten in the Bundesliga on Sunday, while Freiburg beat Cologne.
Paderborn continued their impressive start to their maiden Bundesliga season with a 3-1 win over Hertha Berlin.
Borussia Dortmund progressed through to the last 16 of the DFB-Pokal with a 3-0 victory at St Pauli.
Borussia Dortmund's wretched start to the Bundesliga season continued against Hannover, while Roberto Di Matteo lost his first game at Schalke.
Hamburg's recent mini resurgence was brought to an abrupt end on Saturday as they crashed to a 3-0 defeat to Hertha Berlin.
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