Hoffenheim ended the season with a 2-1 victory over Hertha Berlin.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Hertha Berlin failed to get the mathematical safety they were looking for as they were held to a goalless draw by Frankfurt.
Borussia Dortmund kept up their pursuit of a place in the Europa League thanks to a 2-0 win over Hertha Berlin.
Borussia Monchengladbach moved back up to third in the Bundesliga thanks to a 2-1 win at Hertha Berlin on Sunday
Borussia Monchengladbach moved back into third place with a 2-1 win at Hertha Berlin, while Hamburg saw off Mainz.