Paris Saint-Germain claimed a 3-1 win over Ajaccio in the Coupe de la Ligue round of 16 on Wednesday.
Jeremy Pied's early goal claimed a shock 1-0 win for Guingamp over defending Ligue 1 champions Paris St Germain.
Marseille returned to the top of Ligue 1 with a 3-1 defeat of Metz on Sunday, while Lyon claimed a late 3-2 win at Evian.
Guingamp climbed out of the Ligue 1 relegation zone by beating Reims 3-2 at the Stade Auguste Delaune.
Guingamp moved off the foot of Ligue 1 with a comfortable 5-1 victory over 10-man Caen at the Stade du Roudourou.
Lyon suffered a first defeat since August in Ligue 1 on Sunday night, while Bordeaux claimed a 1-0 win over Lille.
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