Monaco sealed a spot in the Champions League thanks to a 1-0 win at Lorient in the final round of Ligue 1 matches.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
St Etienne beat Guingamp 2-1 but it was not enough to propel them into the Champions League.
Toulouse will play in Ligue 1 next season despite losing 2-1 at mid-table, 10-man Guingamp.
Paris St Germain took a giant leap towards retaining their Ligue 1 title by thrashing Guingamp 6-0 on Friday.
Guingamp made it back-to-back wins in Ligue 1 after seeing off struggling Reims 2-0 on Saturday.