Abiola Dauda scored a hat-trick to lead Vitesse Arnhem to their first Eredivisie win in almost seven months on Sunday.
Go Ahead Eagles recorded their first win of the Eredivisie season with a 1-0 success at home to Willem II.
Willem II beat AZ 3-0 for their first points of the Eredivisie season on Saturday, while Heerenveen also won.
Ajax responded to PSV Eindhoven's statement of intent with a 3-1 victory at AZ Alkmaar in the Eredivisie.
Ajax began their Eredivisie title defence with victory over Vitesse, as Groningen, PSV Eindhoven and Feyenoord also won.
Alireza Jahanbakhsh was NEC Nijmegen's hero with a two-goal haul helping to beat Ajax, condemning Roda JC to the drop.
Real Madrid's Super Cup clash with Sevilla starts a stunning season of European football on Sky Sports 5.
Ajax clinched their fourth successive Eredivisie title with a 1-1 draw against Heracles Almelo on Sunday.
Roda JC's place in the Eredivisie's bottom three was confirmed on Saturday as they fell to a 3-0 defeat to FC Twente.
FC Twente boosted their hope of a top-two finish in the Eredivisie with a 2-0 win at NAC Breda, while PSV were thrashed.
Ajax moved a step closer to their fourth consecutive Eredivisie title with a 2-0 win away at struggling RKC.
Ajax returned to winning ways with a 3-0 home victory over FC Twente while Feyenoord thumped Go Ahead Eagles 5-0.
Eredivisie leaders Ajax were held to a goalless draw at NAC Breda on Sunday, while FC Twente and Feyenoord both won.
Ajax's lead at the top of the Eredivisie has been cut to six points after they drew 1-1 with Cambuur Leeuwarden.
Vitesse moved into second place in the Eredivisie table following a 3-0 victory over bottom side Roda JC on Saturday.
Lasse Schone's hat-trick earned Eredivisie leaders Ajax a 3-0 win over Heerenveen, while Feyenoord drew at NAC Breda.
PSV Eindhoven beat second-placed FC Twente in a five-goal thriller, while Feyenoord hammered NEC Nijmegen.
FC Twente kept the pressure on Eredivisie leaders Ajax with a 2-0 win away at Heerenveen on Wednesday evening.
Real Betis have loaned goalkeeper Stephan Andersen to Eredivisie side Go Ahead Eagles for the remainder of the season.
Ajax beat Go Ahead Eagles to move two points clear at the top of the Eredivisie as Vitesse Arnhem could only draw.