Iago Falque struck twice as Genoa won 4-1 at Atalanta on Sunday to climb to fifth in the standings.
Cagliari's 11-year association with Serie A comes to end after defeat at Palermo, while Ac Milan, Roma and Genoa record win.
Genoa reached seventh place in the Serie A table by keeping European rivals Torino firmly under control in a 5-1 win.
Roma climbed to second place in the Serie A table with a 2-0 home triumph over Genoa on Sunday afternoon.
AC Milan fans spelled out their deepening frustration over the Serie A giants' malaise before the 3-1 defeat to Genoa.
Juventus will have to wait another week to secure their status as Serie A champions after falling to a 2-1 defeat at Torino.