Villarreal, Real Sociedad, PSV Eindhoven and Dinamo Zagreb all enjoyed wins in the Europa League qualifying play-offs.
Feyenoord's bid to start the campaign with back-to-back wins was frustrated by 10-man Heerenveen as they were held 1-1.
Ajax began their Eredivisie title defence with victory over Vitesse, as Groningen, PSV Eindhoven and Feyenoord also won.
Tottenham will take on Cypriot side AEL Limassol in the Europa League play-off round, while Hull face Lokeren.
Demba Ba scored a hat-trick as Besiktas beat Feyenoord 3-1 (5-2 on aggregate) in UEFA Champions League qualifying.
Holland international defender Stefan De Vrij is poised to become a Lazio player after arriving in Italy for a medical.
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