Alireza Jahanbakhsh was NEC Nijmegen's hero with a two-goal haul helping to beat Ajax, condemning Roda JC to the drop.
Ajax clinched their fourth successive Eredivisie title with a 1-1 draw against Heracles Almelo on Sunday.
Zwolle stunned Ajax 5-1 in the Dutch Cup final to claim the first piece of major silverware in their history.
Ajax will have to wait to get their hands on the Eredivisie trophy after Feyenoord matched their victory on Sunday.
FC Groningen boosted their hopes of securing a Europa League play-off berth on Friday with a 1-0 victory at PEC Zwolle.
Ajax returned to winning ways with a 3-0 home victory over FC Twente while Feyenoord thumped Go Ahead Eagles 5-0.
AZ Alkmaar took a big step towards the Europa League play-off places with a 2-1 win over PEC Zwolle on Sunday.
Eredivisie leaders Ajax were held to a goalless draw at NAC Breda on Sunday, while FC Twente and Feyenoord both won.
Vitesse Arnhem kept the pressure up Ajax with a win at NAC Breda in the Eredivisie, while PSV Eindhoven beat FC Utrecht.
Vitesse moved into second place in the Eredivisie table following a 3-0 victory over bottom side Roda JC on Saturday.
PSV Eindhoven claimed a 2-0 win at struggling NEC Nijmegen, while Heerenveen played out a 0-0 draw at NAC Breda.
Lasse Schone's hat-trick earned Eredivisie leaders Ajax a 3-0 win over Heerenveen, while Feyenoord drew at NAC Breda.
Ajax extended their lead at the top of the Eredivisie table to five points with a 1-1 draw away at PEC Zwolle.
Kolbeinn Sigthorsson scored late on as Ajax beat FC Groningen 2-1 to go four points clear at the top of the Eredivisie.
Alfred Finnbogason continued his prolific form this season as Heerenveen with a 3-0 win over ADO Den Haag.
Feyenoord suffered a setback in their bid to breach the Eredivisie's top three after going down 3-2 at ADO Den Haag.
Ajax maintained their bid for a double by reaching the semi-finals of the KNVB Beker with a 3-1 win over Feyenoord.
Vitesse moved three points clear in the Eredivisie with a win at PEC Zwolle on Saturday, while Roda JC held Heerenveen.
A review of the weekend's action so far in the Dutch Eredivisie as Heracles drew with leaders Vitesse.
Vitesse Arnhem and FC Twente will be hoping the speculation surrounding Frank de Boer will unsettle Ajax this weekend.
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