Roberto Di Matteo has resigned as head coach of Schalke, citing "frustration" and a difference of opinion.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Hamburg earned a second chance at securing their Bundesliga status with a 2-0 win over Schalke.
Jerome Boateng has jumped to the defence of brother Kevin-Prince Boateng by claiming Schalke are using him as a scapegoat.
Schalke midfielder Marco Hoeger is free to play in the final match of the season after his club suspension was lifted.
A last-gasp own-goal broke Paderborn hearts as they slumped to a 1-0 defeat at Schalke.
Schalke have released Kevin-Prince Boateng and Sidney Sam in the wake of their 2-0 Bundesliga defeat to Koln on Sunday.
Cologne secured their top-flight status for next season with a 2-0 victory over Schalke.
Bas Dost scored twice as Wolfsburg secured a Champions League spot, while Cologne guaranteed survival.
Schalke ended a six-game winless run as Wolfsburg slipped to defeat, plus all the latest from the Bundesliga.
Florian Klein's late goal kept Schalke on course for the Europa League with a 3-2 win over Stuttgart.
Mainz dealt Schalke's Europa League qualifying hopes a blow while boosting their own with a 2-0 win.
Kevin de Bruyne rescued a point for Wolfsburg against Schalke as they lost ground on leaders Bayern Munich.
Wolfsburg lost ground on Bayern Munich at the top of the Bundesliga after being held to a 1-1 draw by Schalke.
Arsenal and Tottenham are reportedly interested in signing Tom Cleverley as a free agent, according to Sky sources.
Schalke chief Clemens Toennies plans to sign Sami Khedira and doubts reports Benedikt Howedes will join Spurs.
Schalke's hopes of playing in the Champions League suffered a setback after a goalless draw with Freiburg.
Schalke's hopes of a top-four finish receded further after a goalless draw at Augsburg on Sunday.
Augsburg drew 0-0 with Schalke, a result which helps neither side in their respective quests for a place in Europe.
Schalke face an uphill struggle to qualify for the Champions League after falling to a 1-0 defeat to Bayer Leverkusen.