Eric Maxim Choupo-Moting scored a 92nd-minute penalty to earn Schalke a 4-3 win over Sporting Lisbon in Group G.
Roberto Di Matteo celebrated a winning start to life as Schalke coach with his side beating Hertha Berlin 2-0.
Mario Gotze and Philipp Lahm hit braces as Bundesliga leaders Bayern Munich romped to a 6-0 victory over Werder Bremen.
Schalke president Clemens Tonnies has given his support to director of sport Horst Heldt for hiring Roberto Di Matteo.
Roberto Di Matteo has been appointed as the new head coach of German Bundesliga side Schalke.
Hamburg picked up their first Bundesliga win to pile misery on Borussia Dortmund, while Bayern Munich thrashed Hannover.
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