Roberto Di Matteo has resigned as head coach of Schalke, citing "frustration" and a difference of opinion.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Hamburg earned a second chance at securing their Bundesliga status with a 2-0 win over Schalke.
Jerome Boateng has jumped to the defence of brother Kevin-Prince Boateng by claiming Schalke are using him as a scapegoat.
Schalke midfielder Marco Hoeger is free to play in the final match of the season after his club suspension was lifted.
A last-gasp own-goal broke Paderborn hearts as they slumped to a 1-0 defeat at Schalke.