Fiorentina qualified for the Europa League while Stephan El Shaarawy scored his first goal in seven months for AC Milan.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Substitute Samuel Eto'o struck a last-gasp equaliser at Empoli but Sampdoria's European hopes were ended.
Hellas Verona rallied from behind to beat Empoli 2-1 and enhance their chances of finishing in the top half.
Napoli's hopes of Champions League qualification suffered a setback as they drew 2-2 at rock-bottom Parma in Serie A on Sunday.
Fiorentina won 3-2 in a topsy-turvy Tuscan derby meeting with Empoli to remain in the frame to finish fourth in Serie A.
Empoli's long wait for a second away win of the Serie A season came to an end with a 1-0 victory at Torino on Wednesday.
Empoli rocked Napoli's bid for Champions League football with an emphatic 4-2 win at the Stadio Carlo Castellani.
German Denis' last-gasp goal earned Atalanta a valuable point against Empoli on Sunday in Bergamo.
Ishak Belfodil struck a 73rd-minute equaliser as Parma denied Empoli a come-from-behind victory in Sunday's 2-2 draw.
Lazio leapfrogged Roma into second place in Serie A with a resounding 4-0 triumph over Empoli.
A fourth straight Serie A title is Juventus' for the taking after they beat Empoli 2-0 on Saturday night.
Empoli climbed above Sassuolo in the Serie A standings thanks to a 3-1 win at the Stadio Carlo Castellini on Sunday.
Empoli found a late equaliser to secure a 1-1 draw with Cagliari in their Serie A clash on Saturday nigth.
Empoli held Serie A high-fliers Genoa to a 1-1 draw that extended their unbeaten run to six games.
Palermo stretched their unbeaten run at home to 10 Serie A matches with a goalless draw against Empoli.
Massimo Maccarone struck twice after the interval for Empoli as the Tuscan outfit won 3-0 over Chievo on Sunday.
Massimo Maccarone's second-half strike helped Empoli grab a 1-1 draw against AC Milan.
Roma beat Cagliari 2-1 to snap a four-game winless streak and close the gap on Serie A leaders Juventus to seven points.
Empoli halted a nine-game winless run with a comfortable 2-0 home triumph over Cesena on Sunday afternoon.