Valencia qualified for next season's Champions League after winning at Almeria, who were relegated along with Eibar.
Elche missed a string of chances, including a penalty, as they were held to a goalless draw at Levante.
Athletic Bilbao produced a late turnaround to beat Elche 3-2 and move a step closer to qualifying for the Europa League.
Sevilla were held at Celta Vigo as they lost ground on Valencia, while Atletico Madrid drew 2-2 with Levante.
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Villarreal secured sixth position in the Primera Division after scraping past Elche 1-0 at El Madrigal.
Elche coach Fran Escriba believes his team have pulled off a "miracle" in defending their La Liga status.
Elche clinched Primera Division survival by battling to a 2-1 win at Malaga in a thrilling game at La Rosaleda.
Elche took another huge step to clinching top-flight survival by easing to a 4-0 win over Deportivo La Coruna.
Atletico Madrid beat Elche 3-0 at home to resume normal service after being eliminated from the Champions League.
Jonathas de Jesus again proved his worth to Elche by scoring the only goal as his side beat Real Sociedad 1-0
The 1-1 draw between Getafe and Villarreal was overshadowed by a horrible ankle injury to defender Mateo Musacchio.
Cordoba's stay in the Primera Division is fast coming to an end after they went down 2-0 at home to Elche.
Getafe bolstered their hopes of survival by edging to a 1-0 win at struggling Elche.
Elche nudged another point clear of the Primera Division relegation zone with a well-earned 1-1 draw at Espanyol.
Valencia cruised to a comfortable 4-0 win over Elche and strengthen their grip on third place in the Primera Division.
Colombian striker Carlos Bacca scored twice as Sevilla in a 3-0 win at home to Elche.
Elche climbed further away from the Primera Division drop zone after beating Almeria 1-0.
Ahead of the Copa del Rey semi-finals, we look back at the competition's top five moments.