Roma beat Cesena 2-0 on Wednesday night to remain perfect at the Stadio Olimpico this season.
A first-half penalty from Mauro Icardi was enough for Inter Milan to beat 10-man Cesena on Sunday.
Arturo Vidal and Fernando Llorente scored as Serie A leaders Juventus beat Palermo 2-0, while Napoli won 6-2.
Palermo picked up their first win back in Serie A, but they left it late to beat 10-man Cesena 2-1.
Leonardo Bonucci struck the winner four minutes from time as Juventus ended Roma's perfect Serie A run with a 3-2 win.
Emmanuel Cascione's stoppage-time penalty earned promoted Cesena a 1-1 draw at Udinese on Sunday.
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