AZ claim a Europa League place at the expense of Feyenoord, who were consigned to the play-offs for a place in Europe.
NAC Breda face a relegation play-off, while Manchester United-bound Memphis Depay scored for PSV.
AZ Alkmaar remain in contention to clinch a Europa League berth from the Eredivisie after a 2-0 win at FC Twente.
Feyenoord moved a step closer to qualifying for the Europa League after a 2-2 draw at Willem II Tilburg in the Eredivisie.
Markus Henriksen netted a late winner as AZ strengthened their grip on fourth place with a 2-1 win over Cambuur Leeuwarden.
Cash-strapped Twente Enschede returned to winning ways in the Eredivisie on Saturday with a 2-0 win over PEC Zwolle.
AZ Alkmaar had to overcame blustery conditions to beat Willem II 2-0 to reclaim third place in the Eredivisie on Saturday.
Ricardo Kishna struck twice as Ajax beat Twente 4-2 in the Eredivisie to cut PSV's Eredivisie lead back to 12 points.
A calamitous error by Go Ahead Eagles goalkeeper Mickey van der Hart gave parent club Ajax a 2-1 win.
Stefan Nijland scored in each half as PEC Zwolle moved up to third with a thumping 4-0 win at bottom side Dordrecht.
PSV as they scored twice in the last six minutes to defeat Willem II 2-1 on Saturday and extend their Eredivisie lead.
Eredivisie leaders PSV Eindhoven made it six wins in a row as they beat Cambuur 2-1 on Saturday evening.
PSV Eindhoven re-established their four-point lead at the top of the Eredivisie after edging to a 1-0 win at Vitesse.
Manchester City forward Sinan Bytyqi has joined Dutch club SC Cambuur on loan after signing a new two-and-a-half year deal.
There were wins for the Eredivisie's leading sides on Saturday night - and plenty of goals along the way.
PSV Eindhoven reasserted their authority with a 3-0 victory at Go Ahead Eagles on Saturday, while PEC Zwolle recorded a 6-1 win.
FC Utrecht condemned struggling NAC Breda to a fourth consecutive Eredivisie defeat with a 5-1 thrashing on Saturday.
Eredivisie leaders PSV Eindhoven could only draw at FC Groningen on Sunday, while FC Twente beat PEC Zwolle to go third.
PSV Eindhoven retained their four-point lead in the Eredivisie despite free-scoring wins for their nearest pursuers.
Sky Sports understands Cambuur Leeuwarden are in talks with Man City about extending the loan of Albert Rusnak.