Lionel Messi drew level in the race to become the Champions League's all-time top goalscorer as Barcelona beat Ajax 3-1.
PSV Eindhoven strengthened their hold at the top of the Eredivisie as they beat AZ Alkmaar and saw Ajax held by Twente.
PSV Eindhoven pulled two points clear at the Eredivisie summit as fellow high-fliers Ajax and PEC Zwolle drew.
Ajax's stuttering start to their Champions League campaign continued with a frustrating 1-1 draw at APOEL.
Ajax boss Frank de Boer has warned his side Apoel Nicosia will be tough opponents in Tuesday's Champions League clash.
Ajax moved level at the top of the Eredivisie with PSV with a 5-2 win over NAC Breda on a goal-heavy day in Holland.
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