AC Milan had Mattia De Sciglio sent off inside a minute as they slipped to a 3-0 defeat at Napoli in Serie A.
Carlos Tevez scored twice as Juventus beat Fiorentina 3-2 as the Serie A leaders closed in on a fourth straight title.
AC Milan fans spelled out their deepening frustration over the Serie A giants' malaise before the 3-1 defeat to Genoa.
Real Madrid's visit to Juventus pits Andrea Pirlo against his mentor Carlo Ancelotti...
Udinese delivered a potentially knockout blow to AC Milan's hopes of playing in Europe next season by beating them 2-1.
There was victory for Inter Milan over Roma but AC Milan went down to Udinese in Saturday's Serie A fixtures.