Andre Villas-Boas made a winning start to his reign as Tottenham manager on Wednesday, while Southampton enjoyed a comprehensive success.
The dawn of a new era at White Hart Lane saw Spurs put in a professional performance as they saw off Stevenage 2-0 at Broadhall Way.
Summer signing Gylfi Sigurdsson marked his debut with the opening goal early in the second half, and youngster Iago Falque added a second two minutes from time.
Southampton eased to a 4-1 victory over Swiss opponents Etoile-Carouge, with Billy Sharp netting a hat-trick.
Fulham also converted on four occasions as they swept past Lokomotive Leipzig, with new recruit Mladen Petric on the scoresheet for Martin Jol's men.
Marcos Alonso grabbed a rare goal for Bolton as they were held 1-1 by Ayr, but there were no such troubles for the Trotters' Championship rivals Millwall as they hammered Longford 4-1.
League One new boys Swindon put six past Weston, while Hartlepool suffered a 1-0 defeat against Dutch side Almere.
Coventry went down 1-0 to Ross County and fourth tier outfit Wycombe could only muster a goalless draw with Forest Green.
Wrexham got the better of Kilmarnock at the Racecourse Ground with the Blue Square Premier side running out 3-1 winners.
Ross Caldwell gave Hibernian the lead in the 35th minute at SK Lierse, but the Belgian side equalised just before the hour mark secure a 1-1 draw.
Hearts suffered a pre-season blow as they went down 1-0 at First Division side Falkirk.