Monday evening's draw for the last 64 of the Coupe de France produced four all-Ligue 1 ties, highlighted by 10-time champions Marseille taking on Reims.
OM, who dispensed with coach Elie Baup after last week's loss to Nantes and have sporting director Jose Anigo in caretaker charge, are currently fifth in Ligue 1 and lead seventh-placed Reims by only two points.
Fourth-placed Nantes take on Nice in the other stand-out tie while the remaining two top-flight showdowns pair Bastia with Evian and Rennes against Valenciennes.
League leaders Paris Saint-Germain have a tricky draw away to Ligue 2 Brest while Monaco travel to Vannes and third-placed Lille go to Amiens.
Several more of the competition's minnows have the opportunity to face big clubs, with fourth-tier pair Cannes and Raon-l'Etape hosting St Etienne and Bordeaux respectively.
Seventh-tier Bressuire FC take on Sochaux while Olympique Marcquois, from the eighth level, face four-time winners Auxerre.