Carlo Ancelotti won his first Ligue 1 game in charge of Paris St Germain but Montpellier kept the pressure on at the top of the table with a victory over Lyon.
Ancelotti has had a fortnight to work on his strategy for the second half of the league campaign after succeeding Antoine Kombouare at the start of the winter break and, after surviving a cup scare last week, saw his Paris St Germain side easily beat Toulouse 3-1 on Saturday.
Nene did a lot of the damage with a goal in each half, while Javier Pastore also found the target to give PSG a healthy lead.
Daniel Braaten reduced Toulouse's arrears but it came far too late to cause any panic in the PSG ranks.
Montpellier remain just three points adrift at the summit after Olivier Giroud's strike sealed a 1-0 victory over fourth-placed Lyon.
Jires Kembo Ekoko and Victor Montano netted for Rennes to keep them in fifth by virtue of a 2-0 win away to Caen.
St Etienne claimed a narrow 1-0 success at home to struggling Sochaux as Kurt Zouma's header 13 minutes from time boosted their European hopes.
Sochaux are now only above bottom place on goal difference after Ajaccio overcame Auxerre 2-1 in a match which saw three players sent off.
Dennis Oliech broke the deadlock for Auxerre but they then had Anthony Le Tallec dismissed, and Ajaccio took full advantage to move ahead with goals from Eduardo and Fousseni Diawara.
Samuel Bouhours and Armand Maire were then red carded, before half-time, to leave Ajaccio with just nine men, but they held on to their lead to notch a third straight win.
Brest lost 2-0 to Third Division Chamois Niortais in the cup last weekend but Eden Ben Basat's goal proved enough for victory against Nice.
Jussie and Nicolas Maurice-Belay secured a 2-1 victory for Bordeaux over Valenciennes, who pulled a goal back through Foued Kadir but then had Isimat Mirin sent off.
Nancy and Lorient played out an exciting 2-2 draw, with Benjamin Moukannjo's opener for the hosts cancelled out by Mathieu Coutadeur.
Joel Campbell then fired Lorient in front for the first time, only for Salif Sane to retrieve a point for Nancy.
A brace from Brice Jovial and a goal from Benjamon Corgnet helped Dijon to a 3-1 win over ten-man Evian, who scored through Yannick Sagbo but had Eric Tie Bi sent off.