Kevin-Prince Boateng has decided to call time on his international career and focus on his fitness at club level.
The AC Milan midfielder switched his allegiance to Ghana in 2010 having previously turned out for Germany at youth level.
His decision to represent the birthplace of his father paid dividends when he was selected to take part in the 2010 World Cup.
He starred for Ghana as they made their way to the quarter-finals in South Africa.
Boateng has, however, decided to stand down at the age of 24 and with just nine senior caps to his name.
He believes giving his full attention to domestic football will make him a more valuable asset to Milan and will help him to steer clear of injury.
A statement read: "The Ghana Football Association has received a letter from player Kevin-Prince Boateng on his decision to resign from the senior national team, the Black Stars.
"According to Kevin, the physical demands of playing for both club and country at high levels are taking a toll on his health.
"The player also explained that in order to remain healthy and stave off any injuries, he has consulted his doctors and family over the matter and has decided to take the decision to excuse himself from national duties since he is on a special training programme that he has to interrupt to honour national invitations.
"The Ghana Football Association is yet to take a position on the decision of Kevin-Prince Boateng."