The mouth-watering Capital One Cup match-ups between Chelsea and Arsenal then Newcastle and Manchester City are live on Sky Sports this week.
Jose Mourinho, fresh from a Super Sunday win over manchester City, will no doubt have ambitions of trying to complete a third League Cup success with his beloved Blues.
Meanwhile, Manuel Pellegrini will be aiming to bounce back from that Stamford Bridge defeat against a Newcastle side licking their own wounds after going down to fierce rivals Sunderland on Sunday.
The encounters promise to be intriguing affairs and Sky Sports football expert Niall Quinn - who played for Arsenal and Manchester City during his glittering career - assesses the contests and predicts which sides will be in the hat for the quarter-finals.
Tune into Sky Sports to see who comes out on top, while for news of the week's other fourth-round ties - including Manchester United versus Norwich and Leicester against Fulham - catch our Soccer Special programmes on Tuesday and Wednesday (7.30pm, Sky Sports News).
Arsenal v Chelsea (7.30pm, Tue, Sky Sports 1 HD)
Niall says: Chelsea, after their fortuitous but brilliant win against Man City, line up against their old rivals on Tuesday, but there's been a lot of speculation about just how strong Chelsea and Arsenal's respective teams will be.
Jose Mourinho says he may field a weakened side because his stars will not have had time to recover from Sunday, while Arsene Wenger has regularly used this competition to see what he's got and bring young players on. Fans from both sides will remember an inexperienced Arsenal side losing the 2007 League Cup final to Chelsea.
However, it seems to me to field a weaker team in the Capital One Cup may not be appropriate anymore. It's no longer a two-horse race for these trophies, there are perhaps six, seven or eight top teams to overcome. We saw an example of that when Swansea lifted this trophy last season.
Giving up one trophy easily won't sit easily with any of the managers and it will be a big call for them to field a team of youngsters. I'm fascinated to see what way they go.
Arsenal are in a wonderful position in the league and, after a setback in the Champions League, got back on track with a scruffy win over Crystal Palace. Does Wenger believe his senior players need a rest? Or will he patch up that side from the weekend and try to get a result in a hard-fought game with Chelsea?
I suspect - as Mourinho will do with Chelsea - he'll mix it up.
Both sides will speak to their physios and fitness coaches and we'll see a sprinkling of renowned first-team talent and youngsters hoping to make a breakthrough, as both sides try to balance getting the right result and getting to next weekend's Premier League games in good shape.
If that's the case, then I think we can expect a tight game in NorthLondon.
The extra day's rest will help Arsenal but I feel Chelsea's tails are up after the weekend and that gives them the edge. Despite Mourinho talking his team selection down, they are still likely to have Samuel Eto'o up front and I think they will just do enough to progress.
Newcastle v Man City (7.30pm, Wednesday, Sky Sports 1 HD)
Niall says: Jose Mourinho has been complaining about Chelsea's fixtures but Manchester City complete a tough, three away games on the spin with a trip to Newcastle on Wednesday.
After winning at CSKA Moscow and then throwing away a point against Chelsea in the dying moments on Sunday, they continue their Capital One Cup campaign with a visit to St James' Park.
There's no question this tournament is of less value to Manuel Pellegrini and his team than the Champions League - which seems to be his main priority - the Premier League and the FA Cup. But trophies aren't easy to come by and they shouldn't allow this opportunity to pass by easily.
They'll certainly come up against a fired-up Newcastle side, who will be hoping to respond to a disappointing defeat to Sunderland on Sunday.
The best way of getting over a derby defeat is to win your next game. I remember Newcastle beating us 5-1 when I was at Sunderland. We went on a run after that game and, while it didn't eradicate the memory of that defeat, it certainly helped - and Newcastle have an opportunity to do that against a top team who are a little shaken after scraping through a Champions League game and then surrendering a draw at Chelsea.
Joe Hart has come in for criticism for his error against Chelsea and there's speculation, as there was a couple of weeks ago, that Costel Pantilimon will come in for him. But I was in Moscow and saw the City players all run over to Hart at the full-time whistle because he'd won them the match with his breathtaking save from Keisuke Honda in injury time.
A silly decision had enormous consequence on Sunday but is it enough to see him dropped? I don't think so. I personally wouldn't drop him but it will be interesting to see what Pellegrini does and if Pantilimon gets his chance.
For the sake of his confidence, I'd stick with Joe Hart. After a couple of clean sheets, this could all be forgotten.
Pellegrini will have to get his team selection right, though, because Newcastle will put out a strong side and the Magpies are a far better team at home.
I think Newcastle will make it a nervous night for a shell-shocked City camp but there are a lot of players itching to get into that City first XI - players of real quality - and I think the likes of James Milner, who will be coming in, will see City through this tight one.