Non-league Fleetwood and Luton pulled off FA Cup upsets on Saturday, but MK Dons were much too good for Nantwich.
Andy Mangan and Jamie Vardy were the heroes as 10-man Fleetwood saw off League One strugglers Wycombe.
Mangan was on target in the 25th minute for the Blue Square Premier high-fliers, who then had to survive with 10 men for the second half after Richard Brodie was sent off on the stroke of half-time before Vardy's 80th-minute effort made the tie safe.
Fellow Blue Square Premier side Luton giant-killed League Two's Northampton thanks to substitute Adam Watkins' 80th-minute winner.
Michael Rankine saved the blushes of League Two's Aldershot as they salvaged a draw at Blue Square Bet South side Maidenhead, who had taken the lead via Anthony Thomas' seventh-minute opener.
There was no fairytale for Isthmian League Premier Division side East Thurrock, who went down 3-0 at home to League Two's Macclesfield after goals from Carl Tremarco, substitute Matthew Hamshaw and George Donnelly.
Dean Bowditch hit a brace as League One's Milton Keynes Dons hit Nantwich of the Northern Premier League for six.
Blue Square Bet South side Bromley were put to the sword 3-0 at League One Leyton Orient, while Bath City threatened to pull off an upset at League Two's Dagenham & Redbridge when Sean Canham gave the Blue Square Premier bottom side an 11th-minute lead, but Brian Woodall salvaged a replay four minutes before the interval.
Kyle Patterson scored a last-gasp equaliser as Blue Square Premier outfit Tamworth twice came from behind to draw at 10-man Blue Square North side Hinckley, who had keeper Danny Haystead sent off.
Hartlepool also had keeper Scott Flinders dismissed against Stevenage, whose Scott Laird scored the resulting penalty to earn progression at Victoria Park.
Edward Upson, Andy Williams and Dominic Buzzard were on target as League One Yeovil beat League Two's Hereford, while David Noble scored a last-gasp equaliser to earn Exeter a replay against fellow League One side Walsall.
On Sunday, League Two's Morecambe will host League One's Sheffield Wednesday, while Blue Square North outfit FC Halifax face a tough test against League One leaders Charlton.