Chile romped to a 6-0 win over Iraq in Denmark, with Barcelona's Alexis Sanchez inspiring the win.
Esteban Mena opened the scoring just eight minutes in before Sanchez added another two before the half-hour mark.
Wigan's Jean Beausejour then scored twice before Manchester United striker Angelo Henriquez completed the scoring.
Sunderland's Jozy Altidore claimed a hat-trick as USA came from behind to claim a 4-3 win over Bosnia.
Manchester City's Edin Dzeko had opened the scoring on the half-hour, before Elver Rahimic doubled their advantage.
Eddie Johnson pulled one back for USA on 55-minutes before Altidore took control and grabbed his treble.
Dzeko pulled one back in added time but the Americans held on for the win.
Colombia, who are firmly on course for next summer's World Cup finals, claimed a 1-0 win over Serbia in Barcelona with Inter Milan's Fredy Guarin bagging the winner in the final minute.
Asamoah Gyan scored twice in the second-half to give Ghana a 2-2 draw with Turkey in Istanbul. Burak Yilmaz and Umut Bulut had put the hosts two-up before the break.
Croatia only just avoided a shock in Liechtenstein as Eduardo scored with four-minutes left to give them a 3-2 win.
Poland claimed a narrow 3-2 win over Denmark in Gdansk with Piotr Zielinski grabbing the winner on the hour.
Romania and Slovakia played out a 1-1 draw with Slovakia in Bucharest. Bogdan Stancu put the hosts ahead before Stanislav Sestak levelled.
In Kiev, Ukraine claimed a 2-0 win over Israel thanks to goals from Ruslan Rotan and Eugene Seleznev.
Finland got the better of Slovenia with a 2-0 win in Turku.
Ajax defender Niklas Moisander opened the scoring in the first-half before Kasper Hamalainen sealed the win with just eight minutes remaining.
Kalu Uche scored twice to give Nigeria a 2-0 win over South Africa in Durban.
Hungary and Czech Republic played out a 1-1 draw in Budapest. Libor Kozak had given the visitors the lead but Balazs Dzsudzsak levelled from the spot.
South Korea were held to a goalless draw in Suwon by Peru.
Sergey Khizhnichenko's goal after just 17-minutes was enough to give Kazakhstan a 1-0 win over Caspian Sea rivals Georgia.
Juventus star Mirko Vucinic helped Montenegro to a 1-1 draw in Belraus as he levelled on the hour after Sergei Kornilenko opened the scoring in the first-half.
Goals form Agim Ibraimi and Aleksandar Trajkovski gave Macedonia a 2-0 win over Bulgaria.
Iceland claimed a 1-0 win over neighbours Faroe Islands with Birkir Bjarnason claiming the winner.
Marian Pahars's first game in charge of Latvia ended in a 1-1 draw Estonia.