Seven Premier League clubs enter the second round of the Carling Cup on Tuesday night.
Aston Villa, Wolves and Swansea are all hoping to avoid upsets against League Two opposition.
Meanwhile, there are three first round games taking place, with Championship clubs aiming to avoid potential banana skins.
There are 81 positions separating Wolverhampton Wanderersand Northampton Town in the football ladder, but the League Two club host Mick McCarthy's side at the Sixfields Stadium.
Premier League new boys Swansea City go to a Shrewsbury side unbeaten at home in League Two since the beginning of March.
The other top flight club up against a side from the basement division is Aston Villa, who face Hereford, who have picked up just one point in their opening four league games.
West Brom are on their travels after narrow defeats to Manchester United and Chelsea as they go to League One's Bournemouth.
Norwich City have made a steady start to their Premier League campaign and host the MK Dons, who scored six on Saturday.
QPR seek to banish the memories of a 4-0 defeat to Bolton in their last Loftus Road outing as they play League One's slow-starters Rochdale.
Brighton & Hove Albion have made a stunning start to life in the Championship and Steve Bruce's Sunderland have a tough assignment as they visit the AMEX stadium.
There is an all-Yorkshire, all-Championship clash at the Keepmoat Stadium, with Doncaster Rovers up against Leeds United.
Cardiff City are at home to last year's League One play-off finalists Huddersfield Town who grabbed their first win on Saturday.
Other Championship clubs at home to lower-league opposition include Burnley who host Barnet and Millwall who entertain Morecambe.
Leicester are in Lancashire to face Bury and Nottingham Forest head to Wycombe Wanderers.
There are also three first round fixtures to be decided, with Crawley Town making their second appearance in the competition.
The League Two newcomers beat AFC Wimbledon in a qualifier to reach this stage and are rewarded with a trip to near-neighbours Crystal Palace.
Watford, who picked up just their second point of the season at the weekend, go to Paul Buckle's Bristol Rovers.
Charlton and Reading complete a busy night of cup action as the two sides meet at The Valley.